Dissipation and quantization for composite systems

In the framework of 't Hooft's quantization proposal, we show how to obtain from the composite system of two classical Bateman's oscillators a quantum isotonic oscillator. In a specific range of parameters, such a system can be interpreted as a particle in an effective magnetic field, interacting through a spin-orbit interaction term. In the limit of a large separation from the interaction region one can describe the system in terms of two irreducible elementary subsystems which correspond to two independent quantum harmonic oscillators.Comment: 9 page

Black Hole Entropy: a spacetime foam approach

The spacetime foam structure is reviewed briefly (topogical fluctuations and virtual black hole possibility; equation of state of the foam). A model of space foam at the surface of the event horizon is introduced. The model is applied to the calculus of the number of states of a black hole, of its entropy and of other thermodynamical properties. A formula for the number of microholes on the surface of the event horizon is derived. Thermodynamical properties of the event horizon are extended to thermodynamical properties of the space. On the basis of the previous results, the possibility of micro black holes creation by the Unruh Effect is investigated.Comment: 23 pages, no figures, postscript file gzipped,to be published in Classical and Quantum Gravity, July 199

Some Aspects of Minimal Length Quantum Mechanics

String theory, quantum geometry, loop quantum gravity and black hole physics all indicate the existence of a minimal observable length on the order of Planck length. This feature leads to a modification of Heisenberg uncertainty principle. Such a modified Heisenberg uncertainty principle is referred as gravitational uncertainty principle(GUP) in literatures. This proposal has some novel implications on various domains of theoretical physics. Here, we study some consequences of GUP in the spirit of Quantum mechanics. We consider two problem: a particle in an one-dimensional box and momentum space wave function for a "free particle". In each case we will solve corresponding perturbational equations and compare the results with ordinary solutions.Comment: 9 pages, one eps figur

Real-time optical manipulation of cardiac conduction in intact hearts

Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion. Although these interventions have clearly demonstrated the feasibility of cardiac manipulation, current optical stimulation strategies do not take into account cardiac wave dynamics in real time. Here, we developed an all‐optical platform complemented by integrated, newly developed software to monitor and control electrical activity in intact mouse hearts. The system combined a wide‐field mesoscope with a digital projector for optogenetic activation. Cardiac functionality could be manipulated either in free‐run mode with submillisecond temporal resolution or in a closed‐loop fashion: a tailored hardware and software platform allowed real‐time intervention capable of reacting within 2 ms. The methodology was applied to restore normal electrical activity after atrioventricular block, by triggering the ventricle in response to optically mapped atrial activity with appropriate timing. Real‐time intraventricular manipulation of the propagating electrical wavefront was also demonstrated, opening the prospect for real‐time resynchronization therapy and cardiac defibrillation. Furthermore, the closed‐loop approach was applied to simulate a re‐entrant circuit across the ventricle demonstrating the capability of our system to manipulate heart conduction with high versatility even in arrhythmogenic conditions. The development of this innovative optical methodology provides the first proof‐of‐concept that a real‐time optically based stimulation can control cardiac rhythm in normal and abnormal conditions, promising a new approach for the investigation of the (patho)physiology of the heart

Wave Packets Propagation in Quantum Gravity

Wave packet broadening in usual quantum mechanics is a consequence of dispersion behavior of the medium which the wave propagates in it. In this paper, we consider the problem of wave packet broadening in the framework of Generalized Uncertainty Principle(GUP) of quantum gravity. New dispersion relations are derived in the context of GUP and it has been shown that there exists a gravitational induced dispersion which leads to more broadening of the wave packets. As a result of these dispersion relations, a generalized Klein-Gordon equation is obtained and its interpretation is given.Comment: 9 pages, no figur

Minimum black hole mass from colliding Gaussian packets

We study the formation of a black hole in the collision of two Gaussian packets. Rather than following their dynamical evolution in details, we assume a horizon forms when the mass function for the two packets becomes larger than half the flat areal radius, as it would occur in a spherically symmetric geometry. This simple approximation allows us to determine the existence of a minimum black hole mass solely related to the width of the packets. We then comment on the possible physical implications, both in classical and quantum physics, and models with extra spatial dimensions.Comment: 11 pages, 4 figure

Generalized Uncertainty Principle, Extra-dimensions and Holography

We consider Uncertainty Principles which take into account the role of gravity and the possible existence of extra spatial dimensions. Explicit expressions for such Generalized Uncertainty Principles in 4+n dimensions are given and their holographic properties investigated. In particular, we show that the predicted number of degrees of freedom enclosed in a given spatial volume matches the holographic counting only for one of the available generalizations and without extra dimensions.Comment: LaTeX, 13 pages, accepted for publication in Class. Quantum Gra

Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

Recent studies support the potential application of the wt-p53 gene in cancer therapy. Expression of exogenous wt-p53 suppresses a variety of leukaemia phenotypes by acting on cell survival, proliferation and/or differentiation. As for tumour gene therapy, the final fate of the neoplastic cells is one of the most relevant points. We examined the effects of exogenous wt-p53 gene expression in several leukaemia cell lines to identify p53-responsive leukaemia. The temperature-sensitive p53Val135 mutant or the human wt-p53 cDNA was transduced in leukaemia cell lines representative of different acute leukaemia FAB subtypes, including M1 (KG1), M2 (HL-60), M3 (NB4), M5 (U937) and M6 (HEL 92.1.7), as well as blast crisis of chronic myelogenous leukaemia (BC-CML: K562, BV173) showing diverse differentiation features. By morphological, molecular and biochemical analyses, we have shown that exogenous wt-p53 gene expression induces apoptosis only in cells corresponding to M1, M2 and M3 of the FAB classification and in BC-CML showing morphological and cytochemical features of undifferentiated blast cells. In contrast, it promotes differentiation in the others. Interestingly, cell responsiveness was independent of the vector used and the status of the endogenous p53 gene

The Minimum and Maximum Temperature of Black Body Radiation

We show, in different ways, that in the ubiquitous phenomenon of black body radiation there exists a minimum and maximum temperature. These limiting values are so small and large respectively, that they are of no practical use, except in an extreme situation of black hole evaporation where they lead to maximum and minimum mass.Comment: 7 pages, 1 figur